Browsing by Author "Bozkurt, Serhat"

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    Anti-tuberculosis activity of morusin: a promising flavonoid from white mulberry
    (INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D), 2024) Yıldırım, Kübra; Bozkurt, Serhat; Başıbüyük, Hasan Hüseyin; Çoban, Ahmet Yılmaz
    BACKGROUND: TB has remained a significant public health concern from historical times to the present day. Each year, growing drug resistance problems necessitate the discovery of new drugs and drug precursors for TB treatment. Morusin is an important flavone found in the bark of white mulberry ( Morus alba L.) with anti -oxidant, antimicrobial, anti -tumour, anti-inflammatory and antiallergic activity. OBJECTIVE: To determine the anti -TB efficacy of morusin on Mycobacterium tuberculosis strains. DESIGN: Anti -TB efficacy of morusin was tested on H37Ra (American Type Culture Collection [ATCC] 25177), H37Rv (ATCC 27294), ATCC 35822 (isoniazid [INH] resistant), ATCC 35838 (rifampicin [RIF] resistant), and ATCC 35820 (streptomycin [SM] resistant) standard strains and its efficacy was determined using nitrate reductase assay (NRA). RESULTS: The minimum inhibitory concentration (MIC) of morusin was tested in the range of 53.83-0.21 mu g/ml. The MIC for H37Ra (ATCC 25177), H37Rv (ATCC 27294) and ATCC 35838 (RIF -resistant) strains were found to be 6.72 mu g/ml, and this was 13.45 mu g/ml for the ATCC 35822 (INHresistant) and ATCC 35820 (SM-resistant) strains. CONCLUSION: To consider morusin as a viable alternative or precursor drug for TB treatment, it is imperative to conduct an exhaustive examination of its mechanism of action and conduct in vitro studies using clinical isolates.
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    Thermal inactivation of airborne SARS-CoV-2 by an electric fan heater in winter and defining conditions to ensure that all the air passes through the fan
    (ASME, 2024) Canpolat, Murat; Şakalar, Çağrı; Bozkurt, Serhat; Çoban, Ahmet Yılmaz; Karacaylı, Deniz; Toker, Emre
    The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spread, especially in closed environments, by airborne transmission. The study aims to assess the thermal inactivation of airborne SARS-CoV-2 in a 30 m(3) test room as a function of outlet temperature, airflow rate, and operating time of an electric heater, then define a condition to ensure that all air in the room passes through the electric heater. Aerosolized SARS-CoV-2 was delivered to the test room at an ambient temperature of 20 degrees C and 40% humidity. Two electric heaters with different powers and airflow rates were operated respectively in the test room to compare their efficiencies in the inactivation of airborne SARS-CoV-2. The first and second electric heaters had power, airflow rates, and outlet temperatures of 1.5 kW, 44 m(3)/h, 220 degrees C, and 3 kW, 324 m(3)/h, and 150 degrees C, respectively. A fan drew the outside air into the heater. In the first experiment, a 1.5 kW electric heater was operated in the test room for 80 min. In the second experiment, a 3 kW electric heater was used in the test room for 75 min. Airborne SARS-CoV-2 in the test room was inactivated by 99.00% and 99.96% in the first and second experiments, respectively. A condition is defined to ensure that all the air in the room passes at least once through the electric heater fan.