Anti-tuberculosis activity of morusin: a promising flavonoid from white mulberry

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dc.authoridYILDIRIM, KÜBRA/0000-0003-0558-8619
dc.authorwosidYILDIRIM, KÜBRA/HJA-1792-2022
dc.contributor.authorYıldırım, Kübra
dc.contributor.authorBozkurt, Serhat
dc.contributor.authorBaşıbüyük, Hasan Hüseyin
dc.contributor.authorÇoban, Ahmet Yılmaz
dc.date.accessioned2024-08-20T20:29:21Z
dc.date.available2024-08-20T20:29:21Z
dc.date.issued2024
dc.departmentAntalya Belek Üniversitesien_US
dc.description.abstractBACKGROUND: TB has remained a significant public health concern from historical times to the present day. Each year, growing drug resistance problems necessitate the discovery of new drugs and drug precursors for TB treatment. Morusin is an important flavone found in the bark of white mulberry ( Morus alba L.) with anti -oxidant, antimicrobial, anti -tumour, anti-inflammatory and antiallergic activity. OBJECTIVE: To determine the anti -TB efficacy of morusin on Mycobacterium tuberculosis strains. DESIGN: Anti -TB efficacy of morusin was tested on H37Ra (American Type Culture Collection [ATCC] 25177), H37Rv (ATCC 27294), ATCC 35822 (isoniazid [INH] resistant), ATCC 35838 (rifampicin [RIF] resistant), and ATCC 35820 (streptomycin [SM] resistant) standard strains and its efficacy was determined using nitrate reductase assay (NRA). RESULTS: The minimum inhibitory concentration (MIC) of morusin was tested in the range of 53.83-0.21 mu g/ml. The MIC for H37Ra (ATCC 25177), H37Rv (ATCC 27294) and ATCC 35838 (RIF -resistant) strains were found to be 6.72 mu g/ml, and this was 13.45 mu g/ml for the ATCC 35822 (INHresistant) and ATCC 35820 (SM-resistant) strains. CONCLUSION: To consider morusin as a viable alternative or precursor drug for TB treatment, it is imperative to conduct an exhaustive examination of its mechanism of action and conduct in vitro studies using clinical isolates.en_US
dc.identifier.doi10.5588/ijtld.23.0224
dc.identifier.endpage41en_US
dc.identifier.issn1027-3719
dc.identifier.issn1815-7920
dc.identifier.issue1en_US
dc.identifier.pmid38178290en_US
dc.identifier.scopus2-s2.0-85181627000en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage37en_US
dc.identifier.urihttps://doi.org/10.5588/ijtld.23.0224
dc.identifier.urihttps://hdl.handle.net/20.500.14591/125
dc.identifier.volume28en_US
dc.identifier.wosWOS:001222190900006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherINT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)en_US
dc.relation.ispartofInternational Journal Of Tuberculosis And Lung Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMycobacterium tuberculosisen_US
dc.subjectMorus alba L.en_US
dc.subjectmultidrug-resistant TBen_US
dc.subjectreference strainsen_US
dc.titleAnti-tuberculosis activity of morusin: a promising flavonoid from white mulberryen_US
dc.typeArticleen_US

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